منابع مشابه
MOF-associated complexes ensure stem cell identity and Xist repression
Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by targeting promoters and TSS-distal enhancers. In contrast to flie...
متن کاملSearching Chromatin for Stem Cell Identity
Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue ...
متن کاملA Fuzzy Trust model proposal to ensure the identity of a user in time
Access controls ensure that all direct accesses to objects are authorized by means of user identification. However, in some scenarios it is also necessary to continuously check the identity of the user in order to avoid malicious behaviors such as person exchanges immediately after the initial authentication phase. Aim of this work is to propose a methodology based on a balanced mix of strong a...
متن کاملAccepted Manuscript Mof-associated Complexes Ensure Stem Cell Identity and Xist Repression Mof-associated Complexes Ensure Stem Cell Identity and Xist Repression
MOF-associated complexes ensure stem cell identity and Xist repression Thomas Manke, Asifa Akhtar Ramírez, Anne-Valerie Gendrel, Patrick R Wright, Pavankumar Videm, Rolf Backofen, Edith Heard, Tomasz Chelmicki, Friederike Dündar, Matthew Turley, Tasneem Khanam, Tugce Aktas, Fidel http://dx.doi.org/10.7554/eLife.02024 DOI: Cite as: eLife 2014;10.7554/eLife.02024 Published: 19 May 2014 Accepted: ...
متن کاملCAT : the Copying Approach to
The SLG-WAM can be characterized as a sharing approach to implementing tabling: the execution environments of suspended computations are intersperced in the WAM stacks. Stacks are frozen using a set of freeze registers and the WAM trail mechanism is extended so that the suspended computations can be resumed. This technique has a reasonably small execution overhead, but is not easy to implement ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2015
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.349.6250.839-e